Senior Scientist PK/PD and QSP Modeler, Neuroscience
hace 4 semanas
At Jobleads-Us, we are a forward-thinking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Key Responsibilities- Drive decision-making in drug discovery research by building a quantitative model of novel therapeutic agents to treat various neurological diseases including neurodegeneration and neuromuscular diseases.
- Work on cross-functional teams with preclinical biology/pharmacology, chemistry/biologics, nonclinical safety assessment, translational medicine, clinical pharmacology and clinical research to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression.
- Formulate and implement team-engaged right modeling & simulation strategy.
- Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization as well as biomarker selection.
- Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule and safety margin for clinical trials.
- Leverage clinical benchmarking insights from clinical comparators and/or their reverse translation.
- MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
- Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R).
- At least 2 years (8 years with MS) of industry experience in mathematical modeling of biological systems.
- Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions.
- Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical.
- Background or interest in applying modeling and simulation approaches to neurological diseases is preferred.
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Puerto Diablo Barrio, Puerto Rico Jobleads-Us A tiempo completoAbout the RoleTakeda, a world-class R&D organization, is seeking a highly skilled PK/PD and QSP modeler to join our team in Cambridge, MA. In this role, you will interface between biology/pharmacology, chemistry/biologics, nonclinical safety assessment, drug metabolism, translational medicine, clinical pharmacology, and clinical research to influence drug...
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