PK/PD and QSP Modeler, Neuroscience – Senior Scientist Leader

hace 2 semanas


Puerto Diablo Barrio, Puerto Rico Jobleads-Us A tiempo completo

About the Role
Takeda, a world-class R&D organization, is seeking a highly skilled PK/PD and QSP modeler to join our team in Cambridge, MA. In this role, you will interface between biology/pharmacology, chemistry/biologics, nonclinical safety assessment, drug metabolism, translational medicine, clinical pharmacology, and clinical research to influence drug discovery and development.

Key Responsibilities
Drive decision-making in drug discovery research by building a quantitative model of novel therapeutic agents to treat various neurological diseases, including neurodegeneration and neuromuscular diseases.
Work on cross-functional teams to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression.
Formulate and implement a team-engaged modeling and simulation strategy. Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization, and biomarker selection.
Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule, and safety margin for clinical trials.
Leverage clinical benchmarking insights from clinical comparators and/or their reverse translation.

Requirements
MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
Strong competency in building mathematical models is required in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R.
At least 2 years (8 years with MS) of industry experience in mathematical modeling of biological systems.
Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions.
Ability to communicate complex modeling results clearly and concisely to cross-functional audiences is critical.

Benefits
Takeda offers a competitive compensation package, including a base salary range of $133,000.00 - $209,000.00. U.S. based employees may be eligible for short-term and/or long-term incentives, medical, dental, vision insurance, a 401(k) plan, and company match, short-term and long-term disability coverage, basic life insurance, tuition reimbursement, paid volunteer time off, company holidays, and well-being benefits, among others.

Equality and Diversity
Takeda is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information, or other protected characteristics.


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