Principal Associate Scientist, LNP Discovery

hace 4 semanas

Puerto Diablo Barrio, Puerto Rico Jobleads-Us A tiempo completo
Job Summary

We are seeking a highly motivated and innovative Principal Associate Scientist to join our LNP Discovery team at Strand Therapeutics. As a key member of our team, you will be responsible for advancing our mRNA delivery platform and capabilities. Your expertise in LNP formulation and characterization will be crucial in supporting our pipeline programs.

Responsibilities
  • Help advance Strand's mRNA delivery platform and capabilities.
  • Contribute to LNP innovation, engineering, and process screening to support pipeline programs.
  • Characterize the physiochemical properties of LNPs and components using standard or newly developed in-house assays.
  • Evaluate the delivery capability of LNPs using standard or newly developed cell-based assays.
  • Execute LNP composition optimization and screening assays.
  • Compile data reports and communicate the results with relevant team(s).
  • Produce LNP formulations to support internal and partnered programs.
  • Research and identify new opportunities and novel project ideas related to mRNA delivery that support Strand's vision.
  • Write study protocols, technical reports, and SOPs that support the drug discovery efforts of Strand.
Qualifications
  • B.S. or Advanced Degree in Pharmaceutical Sciences, Biomedical Engineering, Chemical Engineering, or other relevant scientific discipline.
  • 5-6+ years of experience with a focus on discovery and development of LNP formulations with nucleic acid-based payloads required.
  • Experience with production and analytical characterization of mRNA LNPs (DLS measurement, RiboGreen assay, luciferase assay, etc.).
  • Experience with mammalian cell culture and cell-based assays is highly preferred.
  • Familiarity with high-throughput screening of mRNA LNPs would be a plus.
  • Excellent knowledge of the scientific literature in the field of mRNA delivery.
  • Highly analytical, decisive, and goal-oriented while maintaining the highest scientific and ethical standards.
  • Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
  • Strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.

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