Senior Bioinformatics Director

hace 3 semanas

Caimito Barrio, Puerto Rico Scribe Therapeutics A tiempo completo

Job Summary

Scribe Therapeutics is a molecular engineering company focused on creating innovative in vivo therapies that address the root causes of diseases. As a leader in the field, we are seeking a highly skilled Associate Director, Bioinformatics to join our team and contribute to the development of our proprietary CRISPR by DesignTM platform.

Key Responsibilities

  • Lead and manage the bioinformatics team to foster a collaborative and innovative environment for CRISPR-based gene editing research and development.
  • Oversee the design, implementation, and analysis of sequencing data, including whole genome/exon sequencing, transcriptomics, epigenomics sequencing, targeted amplicon seq, and off-target discovery NGS sequencing to guide gene-editing experiments.
  • Develop and implement computational workflows for CRISPR off-target analysis, gene function prediction, and target prioritization using genomics and multi-omics data.
  • Collaborate with cross-functional teams to ensure seamless integration of bioinformatics into the R&D pipeline.

Requirements

  • Proficiency in bioinformatics-related programming languages such as Python, R, Perl, and Bash.
  • Expertise in analyzing next-generation sequencing (NGS) data (e.g., RNA-seq, WGS, WES, WGMS, ChIPSeq, single-cell sequencing).
  • Proficiency with tools like Bowtie, BLAST, BWA, GATK, and gene editing-specific software such as CRISPResso.
  • Experience with high-performance computing (HPC) environments and cloud platforms like AWS, Google Cloud, and Azure for handling large datasets.
  • Data visualization skills using tools like ggplot2, Seaborn, Matplotlib, and reproducible HTML reports.

Preferred Qualifications

  • PhD in Computational Biology, Bioinformatics, Genomics or equivalent.
  • At least 8 years of experience working in an academic or industry lab, with a proven track record of hands-on experience developing bioinformatics pipelines and computational biology methods.
  • Familiarity with CRISPR technologies and therapeutic approaches.

What We Offer

We provide a competitive salary, comprehensive medical and other benefits, and opportunities for professional growth in a rapidly growing biotechnology start-up. If you are passionate about advancing CRISPR-based therapeutics, we encourage you to apply.

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