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Scientific Associate Director, GI, Inflammation, Therapeutic Area Lead
hace 4 semanas
At Takeda, we are a forward-thinking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Job SummaryWe are seeking a highly skilled Associate Director to lead our In Vitro Pharmacology team in the GI, Inflammation, and Neuroscience therapeutic areas. As a key member of our Global Biologics organization, you will be responsible for driving innovative research strategies, leading complex scientific projects, and collaborating with cross-functional teams to advance our pipeline.
Key Responsibilities- Lead and innovate in the design, development, and execution of in vitro pharmacology assays to assess the biological activity, mechanism of action, and efficacy of novel biologic therapies targeting GI diseases, inflammation, and neurological disorders.
- Utilize state-of-the-art technologies, such as cell-based assays, co-culture systems, and 3D organoid models, to measure cellular responses in inflammatory pathways, neuronal cell signaling, and gut-brain axis interactions.
- Stay current with scientific advancements and implement new techniques that improve the evaluation of therapeutic candidates.
- Independently design and lead complex scientific projects, contributing to multiple programs as a senior consultant in GI, Inflammation, and Neuroscience.
- Spearhead GI, Inflammation, and Neuroscience biologics discovery programs with cross-functional teams, driving them from lead ID to preclinical development.
- Oversee the screening and profiling of biologic drug candidates in relevant in vitro models, including inflammation-based assays, neuronal models, and GI organoid systems.
- Investigate the molecular mechanisms underlying the activity of therapeutic candidates using in vitro pharmacology approaches.
- Collaborate closely with interdisciplinary teams to align scientific efforts with strategic goals.
- PhD degree in immunology, neuroscience, cell biology, or related fields focusing on GI, inflammatory diseases, or neurological disorders with 7+ years experience, or MS with 13+ years experience, or BS with 15+ years experience.
- Minimum of 6 years of experience in biologics research in Gastroenterology, Inflammation, or Neuroscience, with expertise in relevant biological systems and therapeutic areas.
- Expertise in drug discovery and development processes, including hit identification, lead optimization, candidate selection, and preclinical development.
- Proven track record of leading successful in vitro pharmacology efforts, including assay development and validation, candidate screening, and mechanism of action studies.
- Demonstrated leadership and mentoring skills with experience managing scientific teams and direct reports in laboratory settings.
- Strong technical proficiency in various in vitro techniques and assay formats, including cell-based assays, flow cytometry, and high-content imaging, particularly in inflammatory, GI, and neuronal models.
- Ability to lead cross-functional teams and influence project direction through solid scientific and strategic insights.
- Excellent communication and interpersonal skills to effectively collaborate and lead within a matrixed organization.
- Knowledge of regulatory requirements and guidelines for drug discovery in biologics.
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
