Protein Sciences Team Lead
hace 2 semanas
Ampersand Biomedicines seeks a highly motivated Senior Scientist to join our Protein Sciences team. The successful candidate will play a critical role in antibody discovery, engineering, expression, and purification, as well as their characterization using diverse biophysical and biochemical screening tools.
Key Responsibilities:
- Execute small- and large-scale antibody expression and purification using different chromatography techniques and determine their purity and function using SDS-PAGE, WB, SEC, ELISA, and SPR.
- Design and construct novel antibody variants for improved stability, activity, specificity, or therapeutic potential using diverse molecular biology and analytical techniques.
- Develop and implement multiple high-throughput antibody screening workflows such as ELISA, SPR, blocking, and epitope binning to rapidly identify lead therapeutic candidates with desired biophysical and biochemical profiles.
- Express and purify immunogen and screening reagents using mammalian and E. coli expression systems.
Requirements:
- PhD in Biochemistry, Biomedical Engineering, Structural Biology, or a related discipline with 5+ years of relevant industry experience.
- Background in therapeutic antibody discovery, screening, antibody engineering, and optimization is essential.
- Extensive experience in protein engineering, including design, expression, purification, and characterization using diverse analytical methods is required.
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