Scientist or Senior Scientist

hace 3 semanas

Puerto Diablo Barrio, Puerto Rico Jobleads-Us A tiempo completo

Job Title: Research Scientist: Metabolic Diseases Expert
Job Summary: Dewpoint Therapeutics is seeking an experienced Research Scientist with a deep understanding of metabolic diseases to join our team. The ideal candidate will have a proven track record in setting up and conducting functional assays in human cellular disease models. This role will be instrumental in developing and optimizing functional assays using advanced cellular models (both 2D and 3D) to evaluate the efficacy of potential therapeutic compounds that target metabolic disease pathways.

Key Responsibilities:

  • Develop and optimize functional assays to support the hit-to-lead (H2L) optimization process for small molecule candidates targeting metabolic diseases.
  • Conduct functional assays in human skeletal muscle, human adipocyte, and primary human hepatocyte models.
  • Establish and maintain scalable assays that can be run at a high cadence for effective hit triaging, ensuring relevance to human disease mechanisms.
  • Design and execute experiments to identify compounds that support the Target Product Profile (TPP) in metabolic diseases.
  • Collaborate with cross-functional teams to align assay development with project goals, providing strategic input on assay selection and optimization to ensure the robustness and scalability of the screening cascade.
  • Lead the progression of compounds through the screening decision tree, ensuring relevance to human cells and elucidating the molecular mechanisms underlying observed phenotypes.
  • Integrate omics-based data for target deconvolution and validation to enhance the understanding of metabolic disease pathways and therapeutic intervention points.

Requirements:

  • Ph.D. or equivalent in metabolic diseases or a related field, with a focus on conditions such as diabetes, NASH/MASH, or obesity.
  • At least 5 years of experience in metabolic disease research, with a strong emphasis on hands-on laboratory work and in vitro model development.
  • Extensive experience in developing and conducting functional assays to assess metabolic output.
  • Extensive experience and expertise in working with primary human cells (such as hepatocytes and adipocytes) to study metabolic disease mechanisms.
  • Proven experience with human iPSC culture and differentiation.
  • Deep biological understanding of metabolic disease pathways and mechanisms of action for potential therapeutics.
  • First author metabolic research publication/s in reputed journals.
  • Ability to collaborate in a multidisciplinary and dynamic environment, and experience in mentoring and leading other scientific staff.
  • Ability to communicate effectively in English, the shared language of our multicultural team.

About Dewpoint:
Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases.

Why Join Us:
Dewpoint strives to cultivate an inclusive international community that welcomes and empowers everyone. We reject racism, discrimination, harassment, brutality, and all other manifestations of hate. We draw strength from diversity.
Dewpoint is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

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