Biotherapeutics Research Scientist
hace 2 semanas
Incendia Therapeutics Biotherapeutics Drug Discovery Team
We're seeking an exceptional Senior Scientist to join our Biotherapeutics Drug Discovery group.
About the Role
The successful applicant will support therapeutic antibody discovery and optimization campaigns, including leading reagent generation strategies, developing antibody campaign workplans and screening funnels, overseeing the execution of the campaigns through CRO partners, and optimizing lead antibodies for development candidate selection.
Key Responsibilities
Collaborate with project teams to identify and generate key reagents needed for target validation and antibody campaigns, including proteins, antibodies, and engineered cell lines.
Interface with CRO antibody partners to execute antibody discovery, humanization, and optimization campaigns.
Oversee CROs to produce recombinant proteins and antibodies for in vitro screening and scale-up for in vivo studies, manage in-house inventory, help build LIMS and lab as company grows.
Collaborate with project teams to support Development Candidate nomination, including developing screening funnels and assays to support hit-to-lead identification.
Requirements and Qualifications
Ph.D. + 1-3 years of experience or M.S. + 8-10 years of experience or B.S. + 10-12 years of experience in Biochemistry, Molecular/Cellular Biology, or a related field.
Experience with multiple antibody discovery platforms, including in vivo immunization and in vitro display approaches.
Knowledge of antibody engineering: humanization, affinity maturation, sequence analysis & optimization.
About Incendia Therapeutics
Incendia Therapeutics is a precision oncology company dedicated to reprogramming the tumor microenvironment with the express intent of bringing recalcitrant cancers into submission. We recognize that cancer cells create a hostile microenvironment to privilege their own survival at the expense of the host tissue.
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